Stability of Melphalan Solution for Intravitreal Injection for Retinoblastoma
نویسندگان
چکیده
منابع مشابه
Stability of melphalan solution for intravitreal injection for retinoblastoma.
Stability ofMelphalan Solution for Intravitreal Injection for Retinoblastoma Intravitreal injections for the treatmentof retinoblastomahave been gaining relevance among ophthalmologists, supported by reports on outcome and improvement of the administration technique.1 Currently, doses up to 30 μg per injection are used according to an extensively described technique for intravitreal injection t...
متن کاملIntravitreal melphalan for refractory or recurrent vitreous seeding from retinoblastoma.
OBJECTIVE To evaluate the efficacy and complications of intravitreal chemotherapy for viable vitreous seeding from retinoblastoma. METHODS Intravitreal injection of melphalan (8-50 μg in 0.05 mL) followed by injection site cryotherapy. RESULTS Among 12 treated cases, success with control of vitreous seeds was achieved in 10 of 12 cases at immediate follow-up (0-3 months), 8 of 10 cases at s...
متن کاملIntravitreal and Subconjunctival Melphalan for Retinoblastoma in Transgenic Mice
Purpose. To measure the chemotherapeutic effects of focal melphalan (intravitreal and subconjunctival) on tumor burden, hypoxia, and vasculature in LHBETATAG murine retinoblastoma model. Methods. LHBETATAG transgenic mice were treated with a single 1 mcg intravitreal injection of melphalan, 100 mcg subconjunctival injection, or semiweekly 10 mcg subconjunctival injections for 3 weeks. At 1 or 3...
متن کاملCombined intravitreal melphalan and topotecan for refractory or recurrent vitreous seeding from retinoblastoma.
IMPORTANCE Demonstrating the usefulness and complications of multiagent intravitreal chemotherapy is necessary for successful treatment in patients with recalcitrant vitreous seeding of retinoblastoma. OBJECTIVE To determine the efficacy and complications of combined intravitreal chemotherapy (melphalan hydrochloride and topotecan hydrochloride) for viable vitreous seeding from retinoblastoma...
متن کاملStability of Bevacizumab Divided in Multiple Doses for Intravitreal Injection.
OBJECTIVE To investigate the stability of bevacizumab in multiple doses divided from a single-use vial for intravitreal injection after storage at 4°C for up to six months and under drug transfer condition in tropical climate. MATERIAL AND METHOD Five syringes (0.1 mL, 2.5 mg) of bevacizumab were withdrawn each from five new bevacizumab single-use vials (4 mL, 100 mg) under sterile technique....
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: JAMA Ophthalmology
سال: 2014
ISSN: 2168-6165
DOI: 10.1001/jamaophthalmol.2014.2324